Survey of Drug-Resistant Tuberculosis Patients in a University Tertiary Hospital in Saudi Arabia

  • Reham M. Kaki King Abdulaziz University
  • Nabeela A. Al-Abdullah King Abdulaziz University
  • Mahdi M. Abulkalam King Abdulaziz University
  • Nawaf T. Ashgan King Abdulaziz University
  • Mohammed A. Aldini King Abdulaziz University
  • Abdulrahman M. Dafterdar King Abdulaziz University
Keywords: Drug resistance, Poly-resistant tuberculosis, Saudi Arabia, Multidrug-resistant tuberculosis, Tuberculosis

Abstract

Objective: Drug-resistant tuberculosis is a major health problem worldwide. In Saudi Arabia, 16.4% of tuberculosis cases were found to be resistant to at least one first-line drug. This study aims to assess and determine patterns of tuberculosis drug resistance among patients with culture-positive tuberculosis in order to develop an appropriate treatment strategy.

Methods: Data for 51 patients with culture-proven drug-resistant tuberculosis from January 2006 to January 2017 seeking treatment at the King Abdulaziz University Hospital were retrospectively analyzed. World Health Organization criteria were used to classify cases according to type of resistance: monoresistant, polyresistant, and multidrug resistant.

Results: Of the 299 tuberculosis positive cases there were 51 cases of drug-resistant tuberculosis, of which 60.8% were monoresistant (isoniazid, 17.6%; rifampin, 5.88%; pyrazinamide, 11.76%; ethambutol, 3.92%; streptomycin, 21.57%), 25.49% were multidrug-resistant tuberculosis, and 13.73% were polyresistant. Moreover, 18% involved children, 37% adolescents, 17.6% early adults, 17.6% late adults, and 11.76% elderly. Two-thirds of the patients were non-Saudi (76.46%). We found that 5.8% of the patients were HIV positive and 50% of these patients demonstrated monoresistant tuberculosis. Moreover, 47.05% of patients had type 2 diabetes. A total of 45 (88%) patients had primary resistance and 6 had secondary resistance. Radiologically, 60.78% of the patients had cavitary tuberculosis and 64% had bilateral pulmonary disease.

Conclusions: Our results show that the pattern of tuberculosis drug resistance observed within King Abdulaziz University Hospital is similar to that observed globally. 

Author Biographies

Reham M. Kaki, King Abdulaziz University

Department of Medicine, Department of Infection Disease, Department of Infection Control and Environmental Health

Nabeela A. Al-Abdullah, King Abdulaziz University

Department of Infection Control and Environmental Health

Department of Public Health, College of Nursing

Mahdi M. Abulkalam, King Abdulaziz University

Department of Medicine

Nawaf T. Ashgan, King Abdulaziz University

Department of Medicine

Mohammed A. Aldini, King Abdulaziz University

Department of Medicine

Abdulrahman M. Dafterdar, King Abdulaziz University

Department of Medicine 

Published
2017-12-31
How to Cite
Kaki, R., Al-Abdullah, N., Abulkalam, M., Ashgan, N., Aldini, M., & Dafterdar, A. (2017). Survey of Drug-Resistant Tuberculosis Patients in a University Tertiary Hospital in Saudi Arabia. Saudi Journal of Internal Medicine, 7(2), 27-33. Retrieved from http://sjim.org.sa/index.php/SJIM/article/view/158
Section
Articles

Most read articles by the same author(s)